Common outcome measures for experimental glaucoma models include anatomical counts of retinal ganglion cell (RGC) soma and/or orbital optic nerve axons, which require sacrifice of the animal for histological processing. Experimental models of glaucoma are commonly based on elevated IOP, often induced unilaterally, for example in non-human primates or rodents or in the case of heritable models such as the DBA/2J mouse, IOP becomes chronically elevated in both eyes during the course of aging –. Thus, experimental models of glaucoma are critical for elucidating details of pathophysiological mechanisms as well as for testing new avenues of therapy. Though intraocular pressure (IOP) is the most important treatable risk factor and currently the only target for treatment, the mechanisms by which IOP ultimately damages optic nerve axons remain unclear. Glaucoma is the most common optic neuropathy and is the second leading cause of blindness worldwide. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: Heidelberg Engineering, GmbH provided equipment support. All relevant data are within the paper.įunding: This work was supported by the National Institutes of Health, National Eye Institute Grant: R21-EY021311 (BF), Legacy Good Samaritan Foundation (BF), and Heidelberg Engineering, GmbH (equipment support). This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: The authors confirm that all data underlying the findings are fully available without restriction. Received: ApAccepted: OctoPublished: November 13, 2014Ĭopyright: © 2014 Choe et al. PLoS ONE 9(11):Įditor: Glyn Chidlow, Hanson Institute, Australia Citation: Choe TE, Abbott CJ, Piper C, Wang L, Fortune B (2014) Comparison of Longitudinal In Vivo Measurements of Retinal Nerve Fiber Layer Thickness and Retinal Ganglion Cell Density after Optic Nerve Transection in Rat.
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